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KMID : 1033720170180020105
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Archives of Craniofacial Surgery
2017 Volume.18 No. 2 p.105 ~ p.111
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Metastatic Squamous Cell Carcinoma of the Lower Lip: Analysis of the 5-Year Survival Rate
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Agostini Tommaso
Spinelli Giuseppe
Arcuri Francesco
Perello Raffaella
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Abstract
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Objectives: The author analyse the impact of extracapsular lymph node spread and bone engagement in the ipsilateral neck of patients suffering squamous cell carcinoma (SCC) of the lower lip.
Methods: The data of 56 neck dissections performed in patients suffering SCC of the lower lip between January 2000 and December 2008 were retrospectively analysed. Statistical analysis was performed with the Kaplan-Meier life table method, and the survival rate was investigated with the log rank statistic and significance test. The values were considered statistically significant at p<0.05.
Results: Nine patients took advantage from simultaneous treatment of tumor and prophylactic neck dissection (level I-III), reaching 100% survival rate. Patients suffering metastasized disease, who received radical neck dissection at the time of tumor treatment, presented 83.3% survival rate. Patients who underwent previous surgery and radiotherapy presented worse prognosis although radical neck dissection in case of extra-capsular spread only (24.7%) and osseous engagement (22.2%).
Conclusion: Prophylactic neck dissection (level I?III) is recommended in T3?T4 N0 SCC. Simultaneous treatment of tumor and cervical lymph nodes provides a better prognosis as respect to delayed nodal management. Extra-capsular spread with or without bone engagement represents independent risk factor responsible for high mortality rate of SCC of the lower lip.
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KEYWORD
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Squamous cell carcinoma, Lip, Neck dissection
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